Which of the following ligand-gated ion channels is (are) not regulated primarily by an intracellular signal?

Which of the following ligand-gated ion channels is (are) not regulated primarily by an intracellular signal?



  1. The IP3 receptor located on the endoplasmic reticulum
  2. The potassium-activated calcium channel
  3. The glutamate receptor
  4. The cAMP- and cGMP-gated ion channels
  5. The acid-sensing ion channels

Answer: 3