A lead compound contain a methyl ester functional group was hydrolyzed to give an analogue with a carboxylic acid functional group. An in vivo bio assay which involved oral administration suggested that the ester was active and that the acid was inactive. However, an introit bio assay suggested that the ester was inactive and that the acid was active. What is likely explanation for these results ?

A lead compound contain a methyl ester functional group was hydrolyzed to give an analogue with a carboxylic acid functional group. An in vivo bio assay which involved oral administration suggested that the ester was active and that the acid was inactive. However, an introit bio assay suggested that the ester was inactive and that the acid was active. What is likely explanation for these results ?

A lead compound contain a methyl ester functional group was hydrolyzed to give an analogue with a carboxylic acid functional group. An in vivo bio assay which involved oral administration suggested that the ester was active and that the acid was inactive. However, an introit bio assay suggested that the ester was inactive and that the acid was active. What is likely explanation for these results ?




a. The lead compound fails to get absorbed in the in vivo studies wehreas the carboxylic acid is absorbed and is metabolised to the ester
b. the ester is acting as a product in the in vivo studies
c. the binding site of the target prefers to bind a carbaoxlic acid under in vivro conditions and an ester under in vivo conditions
d. the ester and the carboxylic acid are bothe metabolised to the active compound in vivo



Answer: B


Chemistry

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