A lead compound contianing a methyl ester function group was hydrolyed to gave an analogue with a carboxylic acid functional drop. An 'in vivo' bioassay which involved oral administration suggested that the ester was active and that the acid was inactive. However, an 'in vitro' bioassy suggested that the ester was inactive and that the acid was active. Which of the following is the most likely explaination for these results?

A lead compound contianing a methyl ester function group was hydrolyed to gave an analogue with a carboxylic acid functional drop. An 'in vivo' bioassay which involved oral administration suggested that the ester was active and that the acid was inactive. However, an 'in vitro' bioassy suggested that the ester was inactive and that the acid was active. Which of the following is the most likely explaination for these results?

A lead compound contianing a methyl ester function group was hydrolyed to gave an analogue with a carboxylic acid functional drop. An 'in vivo' bioassay which involved oral administration suggested that the ester was active and that the acid was inactive. However, an 'in vitro' bioassy suggested that the ester was inactive and that the acid was active. Which of the following is the most likely explaination for these results?




a. The ester is an imporant biding group and the carboxylic acid is not
b. The carboxlic acid is an important bidning group but the ester is not
c. Both the carboxylic acid and the ester are important biding groups
d. Neither the carboxylic acid nor the ester ar eimportant binding froup




Answer: B


Chemistry

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