Combretastain is an anti cancer agen discovered rom an African plan. Analogue I is more active than combrestain where as analogue is less active. Which of the following statements is most likely to explain the difference in activity?

Combretastain is an anti cancer agen discovered rom an African plan. Analogue I is more active than combrestain where as analogue is less active.
Which of the following statements is most likely to explain the difference in activity?




a. Rigidification has locked analogue 1 into the active confomation and locked analogue 11 into an inactive conformation
b. Rigidificaiton has locked analogue 11 into the active conformation an dlocked analogue 1 into the inactive conformation
c. Rigidification has locked both analogues 1 and 11 into the active conformation
d. Rigidifcaiton has locked both 1 and 11 into the inactive conformation




Answer: A


Chemistry

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