Struction I is an antihypertensive agent which acts by inhibiting the enzyme ACE. Structure II was designed to bind to the binding site more strongly and to have greater activity.
Which of the following stratergies was used in the design of II?
a. Simplification
b. Rigidification
c. Use of an isoatere
d. Extension
Answer: D
Chemistry
- Which of the following objects, all moving at the same speed, will have the highest de Broglies wavelength?
- Which of the following is a correct formation reaction?
- Which of the following gases will be the fastest to diffuse through a room?
- Indicate the gas with the greatest density at 2.3 atm pressure and 22C degrees.
- Which of the following substances is a strong acid?
- Which of the following is a weak base?
- Which of the following is a redox reaction?
- Which of the following will produce a precipitate?
- Which of the following is not ionic?
- Which of the following will be the poorest conductor of electrical current when dissolved in water, assuming equal concentrations?
- Which of the following is a main group metal?
- Which of the following elements is liquid at room temperature?
- Predict the charge that an ion formed from selenium would have.
- Which of the following has the greatest number of electrons?
- An element with the atomic number twelve
- Which of the following is approximately room temperature?
- If the distance between two charged particles is halved, the electrostatic force between them?
- Which represents the largest volume?
- Which of the following is not an Si base unit?
- The process of adding a known amount of solution of known concentration to determine the concentration of another solution is called
- What characterizes a strong acid or base
- Which of these solutions is the most basic
- What is pH
- What is the charge on the hydronium ion
- Which of the following represents a Bronsted-Lowry conjugate acid-base pair