Structure III is a serotonin antagonist. A methyl group has been introducing into analogue IV resulting in increased activity. What strategy has been used here?

Structure III is a serotonin antagonist. A methyl group has been introducing into analogue IV resulting in increased activity. What strategy has been used here?

Structure III is a serotonin antagonist. A methyl group has been introducing into analogue IV resulting in increased activity.

What strategy has been used here?




a. Extension
b. Rigidification
c. Conformational blocking
d. Isosteric replacement




Answer: C