What is granulomatous inflammation?
chronic
morphological features: infiltration of mononuclear cells: lymphocytes, plasma cells, macrophages
tissue destruction b persistent offending agent or by the inflammatory cells
attempts at healing; replacement of damaged tissue, angiogenesis, fibrosis
outcome: encapsulating stimulus, proliferation of fibroblats can affect organ function, extend of debilitation depends on location of the lesion; debiliting by continuous release of inflammatory mediators TNF, IL1