What is healing of a long bone fracture?
Answer:
1. removeal of necrotic bone and debris by macrophages and osteoclasts
2. angiogenesis and fibroblast proliferation
3. callus formation: pluripotential mesenchymal cells from the soft tissue, periosteium and bone marrow proliferate and differentiate, composed of fibrous tissue, cartilage and bone, fusion of osteogenic layers on either side of the callus
4. remodeling phase: newly formed woven bone is gradually converted to lamellar bone, at about 8 weeks the callus is called a secondary or hard callus and it consists mainly of bone
5. stage of consolidation: endocondrial ossification of the cartilage continues, trabecular bone replaces cartilage, the new bone is continuously remodelled and eventually replaced by compact bone, dead bone removed before healing can be completed, eventually the oritinal line of the bone is restored (takes years)
Pathology
- Outline the five steps involved in general wound healing
- What is the repair of peripheral nerves?
- What is repair of skeletal muscle?
- What is repair of articular cartilage with injuries that involve subchondral bone?
- What is repair of articular cartilage with erosions, superficial defects?
- What is repair of articular cartilage?
- What is second intention healing of cutaneous wound healing?
- What is the process of epithelialization?
- What are the processes of cutaneous wound first intention healing?
- Briefly describe the pathogenesis of granulation tissue formation in a wound, highlighting the important gross and microscopic features.
- What are the types of edema?
- What are the three mechanisms to edema formation?
- What are consequences of hemorrhage?
- What is aetiology of haemorrhage?
- What are the different classifications of haemorrhage?
- What is congestion?
- What is role of platelets in inflammation?
- What is role of macrophages?
- What are granules in eosinophils?
- What is the role of eosinophils?
- What is the role of mast cells?
- What is the role of neutrophils?
- There are three steps involved in tumour development/transformation: initiation, promotion and progression. For each of these three steps state if the effect is permanent or not, indicating why in each case.
- Name one benign and one malignant tumour commonly found in the dog.