What is the process of epithelialization?
Answer:
process of replacement of superficial epithelial cells of skin and mucous membranes: epithelial cells at the wound edge dissasemble connection with basement membrane and adjacent cells, cells express as new surface receptors, movement of cells over the ECM of wound surface, epithelial cells at edge of the wound proliferate
once cells have filled defect they differentitate
inact basement membranes enhance reepithelialization
concurrent inflammation can impair differentiation
concurrent inflammation can impair differentiation: impairs/delays epithelializaiton, ulceration, continuous attempts to cover wound, metaplasia