What is repair of skeletal muscle?
Answer:
skeletal muscle cells ar long multinucleated, permanent cells
myonuclei ar unable to divide
1. macrophages clean up intracelular debris
2. satellite cells, mitosis --> myoblasts --> migrate from marginal site to centre of myobibrils, new myofiber nuclei
3. intact basal lamina: keeps both satellite cells and their myoblast progeny within damaged segment, keeps fibroblasts out, allows entry and exit of macorphages
4. after critical mass of myoblasts have formed they begin to fuse to form myotubular giant cells
5. myotubes sent out numerous cytoplasmic processes of which re-establish contact with the original muscle cell
6. cell membranes fuse to facilitat union of regenerated segment with vable myofibre
Pathology
- Outline the five steps involved in general wound healing
- What is healing of a long bone fracture?
- What is the repair of peripheral nerves?
- What is repair of articular cartilage with injuries that involve subchondral bone?
- What is repair of articular cartilage with erosions, superficial defects?
- What is repair of articular cartilage?
- What is second intention healing of cutaneous wound healing?
- What is the process of epithelialization?
- What are the processes of cutaneous wound first intention healing?
- Briefly describe the pathogenesis of granulation tissue formation in a wound, highlighting the important gross and microscopic features.
- What are the types of edema?
- What are the three mechanisms to edema formation?
- What are consequences of hemorrhage?
- What is aetiology of haemorrhage?
- What are the different classifications of haemorrhage?
- What is congestion?
- What is role of platelets in inflammation?
- What is role of macrophages?
- What are granules in eosinophils?
- What is the role of eosinophils?
- What is the role of mast cells?
- What is the role of neutrophils?
- There are three steps involved in tumour development/transformation: initiation, promotion and progression. For each of these three steps state if the effect is permanent or not, indicating why in each case.
- Name one benign and one malignant tumour commonly found in the dog.