For years, the only medication Jayla has taken to help with her severe knee pain is an NSAID. She has just been diagnosed with cancer and is to be treated with, among other agents, methotrexate. What is the potential interaction between the methotrexate and the NSAID?
potentiation and increased risk of adverse effects of the NSAID
decreased effectiveness of methotrexate
potentiation and increased risk of methotrexate toxicity
decreased effectiveness of the NSAID
Answer: potentiation and increased risk of methotrexate toxicity