A clinical nurse specialist (CNS) is orienting a new graduate registered nurse to an oncology unit where blood product transfusions are frequently administered. In discussing ABO compatibility, the CNS presents several hypothetical scenarios. The new graduate knows that the greatest likelihood of an acute haemolytic reaction would occur when giving:
a) O-negative blood to an O-positive client.
b) A-positive blood to an A-negative client.
c) O-positive blood to an A-positive client.
d) B-positive blood to an AB-positive client.
Answer: A-positive blood to an A-negative client.