Functional neuroimaging studies (by Drevets and Raichle) of subjects with unipolar depression have shown:
- decreased blood flow in the amygdala and specific areas in the prefrontal cortex.
- no difference in blood flow patterns between depressed and non-depressed subjects.
- abnormal blood flow in specific prefrontal cortical areas that continues even after resolution of depressive symptoms.
- increased blood flow in the amygdala and specific areas in the prefrontal cortex.
- increased blood flow in all limbic structures.
Answer: 4