Which of the following statements about the LTD mechanism in cerebellar Purkinje cells is false?

Which of the following statements about the LTD mechanism in cerebellar Purkinje cells is false?

Which of the following statements about the LTD mechanism in cerebellar Purkinje cells is false?





  1. Alternating activation of climbing fibers and parallel fibers is required to induce LTD.
  2. The firing of parallel fibers activates mGluR receptors and generates IP3.
  3. Climbing fibers generate a large calcium signal in Purkinje cell dendrites.
  4. Both IP3 and calcium are required to activate the IP3 receptors and depress AMPA receptor activity.
  5. The strength of the parallel fiber synapses can be depressed for a long period of time.

Answer: 1