What is currently the best explanation for what determines whether a T cell develops into a CD8+ T cell or a CD4+ T cell?

What is currently the best explanation for what determines whether a T cell develops into a CD8+ T cell or a CD4+ T cell?











A. CD4/TCR coengagement suppresses CD8 expression, and CD8/TCR coengagement suppresses CD4 expression.
B. T cells randomly down-regulate CD4 or CD8, and only cells that still bind the appropriate MHC will get a strong enough signal to survive.
C. CD4 or CD8 expression is determined by the strength and duration of the TCR/MHC interaction.
D. CD4 or CD8 expression is predestined in the bone marrow.
E. Only ?d T cells express CD8.














Answer: C


Biology

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