Which of the following BEST describes the relationship between natural TREGs and induced TREGs?
A. Natural TREGs differentiate into induced TREGs in response to stimulation through the TCR.
B. Natural TREGs are derived from memory T cells, and induced TREGs differentiate directly from developing thymocytes.
C. Natural TREGs develop in the thymus, and induced TREGs develop in the periphery.
D. Natural TREGs have less diverse TCRs than induced TREGs.
E. None of the above
Answer: C