Which of the following observations would demonstrate the spike timing-dependent plasticity of synapses?

Which of the following observations would demonstrate the spike timing-dependent plasticity of synapses?

Which of the following observations would demonstrate the spike timing-dependent plasticity of synapses?




  1. Whether or not LTP occurs depends on the specific temporal pattern of action potentials.
  2. LTP occurs whenever an action potential precedes an EPSP.
  3. LTD occurs whenever an action potential follows an EPSP.
  4. Switching the relative timing of action potential and EPSP by as little as 20 ms can switch the response from LTD to LTP, or vice-versa.
  5. A rhythmic pattern of spike-EPSP-spike-EPSP, at 40 ms intervals, produces maximal LTP.

Answer: 4